Yes. The systems take into account many conditions.

Customer time parameters
Specific days and time windows, fixed and variable stop length adjustable according to capacity data, etc.

Quantity/capacity parameters
Can be combined, for example, weight of goods, number of pieces, volume, loading area, etc.

Vehicle properties
For each order, specify the requirements that the vehicle must meet (e.g. lifting platform, delivery by a specific vehicle, etc.)
Different departure points, depots and places for vehicle return, AETR, multiple departures of one vehicle, etc.

Cost parameters
Costs per distance unit (CZK/km), hourly costs (CZK/hour), zone/flat rate costs (e.g. up to/over 100km), fixed costs, penalties for not fulfilling the order.

Vehicles do not have to have a fixed end of the route
They can end at the last order (optimally sorted). Often used when using the services of external carriers.
The route can be ended at a given location outside the depot. For example, drivers take the vehicles home.

Working with homogeneous types of products such as milk, sand, bricks, etc.
Places where the product is produced or where it is to be delivered; places have a need / maximum quantity / minimum delivered / collected; places can give different evaluations of the product delivered; certain vehicles cannot go to certain places.

Orders can be delivered / distributed to multiple places (depots).
The system selects suitable places based on the optimization of transport costs. Can be set up, for example, according to group types.

They can also model situations with semi-trailers/trailers.

And many more…

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